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Therapeutic Attitude in the Malignification of Pilonidal Cyst: Radical Treatment Associating Intraoperative Radiotherapy

Received: 7 December 2019     Accepted: 26 December 2019     Published: 8 January 2020
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Abstract

Malignant degeneration on pilonidal cyst is an infrequent entity: less than 70 cases have been described in the literature. Predominantly in males around 50-60. Very slow evolution until its malignancy. Predilection for the sacrococcygeal area and epidermoid histology. Infrequent distant dissemination despite the important local extension of the primary tumor. Similar morphological and histological characteristics to anal carcinomas, using schemes of treatment based on radiotherapy and chemotherapy with radical intention according to locoregional and distance extension, associating subsequent surgery depending on the response. We describe a case of this pathology and its therapeutic management based on the literature review available. We present the case of a 70-year-old man with a pilonidal cyst malignancy in the sacrococcygeal region. Locally advanced and unresectable disease at diagnosis with skin, muscle, lymphatic and bone involvement. Pathological confirmation diagnosis established after thick needle biopsy, with a well-differentiated squamous cell carcinoma. It was decided to administer chemotherapy and radiotherapy treatment and, depending on the response evaluated by nuclear magnetic resonance, excision and/or intraoperative radiotherapy in the area of microscopic risk disease. In a second time, reconstruction using glute flaps. Early diagnosis and treatment are essential to improve the unfortunate prognosis. Surgery with curative intention is the standard of care according to locoregional extension in association with radiotherapy and chemotherapy if adverse factors or unresectable disease. In order to enhance local control, dose has been scaled allowing, besides, to minimize the acute toxicity derived from the treatment.

Published in International Journal of Clinical Oncology and Cancer Research (Volume 5, Issue 1)
DOI 10.11648/j.ijcocr.20200501.12
Page(s) 5-9
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Malignancy of Pilonidal Cyst, Radiotherapy, Intraoperative Radiotherapy, Neoadjuvant Treatment, Sacrococcygeal Area, Surgery

References
[1] Michalopoulos N, Sapalidis K, Laskou S, Triantafyllou E, Raptou G, Kesisoglou I. “Squamous cell carcinoma arising from chronic sacroccocygeal pilonidal disease: a case report”. World J Surg Oncol. 2017; 15 (1): 65.
[2] Cruz-Mendoza I, Hernández-Jesús B, López-Pérez E, Flores-Cobos AE, García-Rodríguez F. “Tumor epidermoide moderadamente diferenciado asociado con quiste pilonidal”. Cirugía Cir. 2014; 82 (1): 87-92.
[3] Alarcón-del Agua I, Bernardos-García C, Bustos-Jiménez M, Serrano-Borrero I, Casado-Maestre MD, Docobo-Durantez F. “Denegeración maligna sobre quiste pilonidal”. Cirugía Cir. 2011; 79 (4): 373-378.
[4] Jaime SP, Julve JV, Alzamora MS, Santaló NB, Millán CV, Barón RE. “Malignización de los sinus pilonidales: tratamiento”. Oncol. Rev. 2002; 4 (6): 331-334.
[5] Nunes LF, Pitta de Castro AK, Vasconcelos RAT, Cajaraville F, Castilho J, Netto JF, Silva W. “Carcinomatous degeneration of pilonidal cyst with sacrum destruction and invasion of the rectum”. An Bras Dermatol. 2013; 88 (6): 59-62.
[6] Ramazan E, Tuna B, Ismail O, Orhan Veli O, Aytekin C, Mustafa S. “Recurrent squamous cell carcinoma arising in a neglected pilonidal sinus: report of a case and literature review”. Int J Clin Exp Med. 2014; 7 (2): 446-450.
[7] De Bree E, Zoetmulder FA, Christodoulakis M, Aleman BM, Tsiftsis DD. “Treatment of malignancy arising in pilonidal disease”. An. Surgery Oncol. 2001; 8 (19): 60-64.
[8] NCCN Clinical Practice Guidelines in Oncology, Anal carcinoma [Internet]. Nccn.org. 2018 [cited 6 May 2019]. Available from: https://www.nccn.org/professionals/physician_gls/default.aspx.
[9] Meulendijks D, Dewit L, Tomasoa NB, Van Tinteren H, Beijnen JH, Schellens JH, Cats A. “Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option”. Br J Cancer. 2014; 111 (9): 1726–1733. doi: 10.1038/bjc.2014.467.
[10] RTOG Radiation Foundation INC, Anorectal Counturing Guidelines [Internet]. Rtog.org. 2019 [cited 11 May 2019]. Available from: https://www.rtog.org/CoreLab/ContouringAtlases/Anorectal.aspx.
[11] Kachnic L, Winter K, Myerson R, Goodyear MD, Willins J, Esthappan J, Haddock MG, Rotman M, Parikh PJ, Safran H, Willett CG. “RTOG 0529: A Phase 2 Evaluation of Dose-Painted Intensity Modulated Radiation Therapy in Combination With 5-Fluorouracil and Mitomycin-C for the Reduction of Acute Morbidity in Carcinoma of the Anal Canal”. Int J Radiat Oncol Biol Phys. 2013; 86 (1): 27-33.
[12] Cooperative Group Common Toxicity Criteria [Internet]. Rtog.org. 2019 [cited 6 May 2019]. Available from: https://www.rtog.org/ResearchAssociates/AdverseEventReporting/CooperativeGroupCommonToxicityCriteria.aspx.
[13] Park BS, Shin DH, Kim SH, Jung HJ, Son GM. “Perineal squamous cell carcinoma arising from an epidermal cyst: a case report”. World J Surg Oncol. 2018; 16 (1): 155.
[14] Boukalik W, Salwan F. “Squamous Cell Carcinoma Arising in a Pilonidal Sinus”. An Surgery. 1962; 156 (1): 157-160.
[15] Cardona-Hernández MA, Fierro-Arias L, González-González M, Ávila Medrano L. “Carcinoma epidermoide de alto riesgo originado en úlcera de Marjolin. Tratamiento alternativo con radioterapia”. Dermatol. Rev. Mex. 2014; 58: 267-273.
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  • APA Style

    Natalia Noblejas Quiles, Virginia Morillo Macías, Araceli Mayol Oltra, Fernando Ibáñez Palacín, Jorge Molina Saera, et al. (2020). Therapeutic Attitude in the Malignification of Pilonidal Cyst: Radical Treatment Associating Intraoperative Radiotherapy. International Journal of Clinical Oncology and Cancer Research, 5(1), 5-9. https://doi.org/10.11648/j.ijcocr.20200501.12

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    ACS Style

    Natalia Noblejas Quiles; Virginia Morillo Macías; Araceli Mayol Oltra; Fernando Ibáñez Palacín; Jorge Molina Saera, et al. Therapeutic Attitude in the Malignification of Pilonidal Cyst: Radical Treatment Associating Intraoperative Radiotherapy. Int. J. Clin. Oncol. Cancer Res. 2020, 5(1), 5-9. doi: 10.11648/j.ijcocr.20200501.12

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    AMA Style

    Natalia Noblejas Quiles, Virginia Morillo Macías, Araceli Mayol Oltra, Fernando Ibáñez Palacín, Jorge Molina Saera, et al. Therapeutic Attitude in the Malignification of Pilonidal Cyst: Radical Treatment Associating Intraoperative Radiotherapy. Int J Clin Oncol Cancer Res. 2020;5(1):5-9. doi: 10.11648/j.ijcocr.20200501.12

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  • @article{10.11648/j.ijcocr.20200501.12,
      author = {Natalia Noblejas Quiles and Virginia Morillo Macías and Araceli Mayol Oltra and Fernando Ibáñez Palacín and Jorge Molina Saera and Rafael Lozoya Albalar and Enrique Boldó Roda and Stephane Antonio De Francia Cachon and María Eloísa Villaverde Domenech and Isabel Busquier Hernández and Carlos Ferrer Albiach},
      title = {Therapeutic Attitude in the Malignification of Pilonidal Cyst: Radical Treatment Associating Intraoperative Radiotherapy},
      journal = {International Journal of Clinical Oncology and Cancer Research},
      volume = {5},
      number = {1},
      pages = {5-9},
      doi = {10.11648/j.ijcocr.20200501.12},
      url = {https://doi.org/10.11648/j.ijcocr.20200501.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20200501.12},
      abstract = {Malignant degeneration on pilonidal cyst is an infrequent entity: less than 70 cases have been described in the literature. Predominantly in males around 50-60. Very slow evolution until its malignancy. Predilection for the sacrococcygeal area and epidermoid histology. Infrequent distant dissemination despite the important local extension of the primary tumor. Similar morphological and histological characteristics to anal carcinomas, using schemes of treatment based on radiotherapy and chemotherapy with radical intention according to locoregional and distance extension, associating subsequent surgery depending on the response. We describe a case of this pathology and its therapeutic management based on the literature review available. We present the case of a 70-year-old man with a pilonidal cyst malignancy in the sacrococcygeal region. Locally advanced and unresectable disease at diagnosis with skin, muscle, lymphatic and bone involvement. Pathological confirmation diagnosis established after thick needle biopsy, with a well-differentiated squamous cell carcinoma. It was decided to administer chemotherapy and radiotherapy treatment and, depending on the response evaluated by nuclear magnetic resonance, excision and/or intraoperative radiotherapy in the area of microscopic risk disease. In a second time, reconstruction using glute flaps. Early diagnosis and treatment are essential to improve the unfortunate prognosis. Surgery with curative intention is the standard of care according to locoregional extension in association with radiotherapy and chemotherapy if adverse factors or unresectable disease. In order to enhance local control, dose has been scaled allowing, besides, to minimize the acute toxicity derived from the treatment.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Therapeutic Attitude in the Malignification of Pilonidal Cyst: Radical Treatment Associating Intraoperative Radiotherapy
    AU  - Natalia Noblejas Quiles
    AU  - Virginia Morillo Macías
    AU  - Araceli Mayol Oltra
    AU  - Fernando Ibáñez Palacín
    AU  - Jorge Molina Saera
    AU  - Rafael Lozoya Albalar
    AU  - Enrique Boldó Roda
    AU  - Stephane Antonio De Francia Cachon
    AU  - María Eloísa Villaverde Domenech
    AU  - Isabel Busquier Hernández
    AU  - Carlos Ferrer Albiach
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    PY  - 2020
    N1  - https://doi.org/10.11648/j.ijcocr.20200501.12
    DO  - 10.11648/j.ijcocr.20200501.12
    T2  - International Journal of Clinical Oncology and Cancer Research
    JF  - International Journal of Clinical Oncology and Cancer Research
    JO  - International Journal of Clinical Oncology and Cancer Research
    SP  - 5
    EP  - 9
    PB  - Science Publishing Group
    SN  - 2578-9511
    UR  - https://doi.org/10.11648/j.ijcocr.20200501.12
    AB  - Malignant degeneration on pilonidal cyst is an infrequent entity: less than 70 cases have been described in the literature. Predominantly in males around 50-60. Very slow evolution until its malignancy. Predilection for the sacrococcygeal area and epidermoid histology. Infrequent distant dissemination despite the important local extension of the primary tumor. Similar morphological and histological characteristics to anal carcinomas, using schemes of treatment based on radiotherapy and chemotherapy with radical intention according to locoregional and distance extension, associating subsequent surgery depending on the response. We describe a case of this pathology and its therapeutic management based on the literature review available. We present the case of a 70-year-old man with a pilonidal cyst malignancy in the sacrococcygeal region. Locally advanced and unresectable disease at diagnosis with skin, muscle, lymphatic and bone involvement. Pathological confirmation diagnosis established after thick needle biopsy, with a well-differentiated squamous cell carcinoma. It was decided to administer chemotherapy and radiotherapy treatment and, depending on the response evaluated by nuclear magnetic resonance, excision and/or intraoperative radiotherapy in the area of microscopic risk disease. In a second time, reconstruction using glute flaps. Early diagnosis and treatment are essential to improve the unfortunate prognosis. Surgery with curative intention is the standard of care according to locoregional extension in association with radiotherapy and chemotherapy if adverse factors or unresectable disease. In order to enhance local control, dose has been scaled allowing, besides, to minimize the acute toxicity derived from the treatment.
    VL  - 5
    IS  - 1
    ER  - 

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Author Information
  • Department of Radiation Oncology, Consorcio Hospitalario Provincial de Castellon, Castellon, Spain

  • Department of Radiation Oncology, Consorcio Hospitalario Provincial de Castellon, Castellon, Spain

  • Department of General Surgery, Consorcio Hospitalario Provincial de Castellon, Castellon, Spain

  • Department of Medical Oncology, Consorcio Hospitalario Provincial de Castellon, Castellon, Spain

  • Department of General Surgery, Consorcio Hospitalario Provincial de Castellon, Castellon, Spain

  • Department of General Surgery, Consorcio Hospitalario Provincial de Castellon, Castellon, Spain

  • Department of Plastic Surgery, Consorcio Hospitalario Provincial de Castellon, Castellon, Spain

  • Department of Plastic Surgery, Consorcio Hospitalario Provincial de Castellon, Castellon, Spain

  • Department of Medical Oncology, Consorcio Hospitalario Provincial de Castellon, Castellon, Spain

  • Department of Radiation Oncology, Consorcio Hospitalario Provincial de Castellon, Castellon, Spain

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