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The Association of Toxoplasma gondii Infection in Breast and Colorectal Cancer Patients

Received: 14 July 2017     Accepted: 25 July 2017     Published: 18 August 2017
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Abstract

Toxoplasma gondii is an obligatory intracellular protozoan parasite which is a major opportunistic pathogen in patients who are immunocompromised that having cancer disease. Little is known about the epidemiology of T. gondii infection in patients who are immunocompromised. This study investigate the possible association of T. gondii infection with cancer disease via determining the seropositivity rate of anti T. gondii antibodies (IgG and IgM) in Iraqi patients infected with breast and colorectal cancer and investigate the level of IL-6 in the studying groups. Overall 223 women serum samples that included 112 healthy controls samples and 111 samples with breast cancer (CA. Breast) and colorectal cancer (CA. CRC) enrolled in this study. The participants were tested for T. gondii immunoglobulins (IgG and IgM) antibodies and (IL-6) levels. The results showed that 86 (77.46%) cancer sample out of 111 samples and 23 (20.54%) out of 112 control samples were positive to anti T. gondii IgG. The seropositive rate of anti T. gondii IgG in CA. Breast and CA. CRC patients (77.50%, 77.42%) respectively compared with control group (20.54%). The present results revealed that the higher percentages for anti-T. gondii IgG and IL-6 titer was among patients with CA. Breast and CA. CRC whose are seropositive to anti T. gondii IgG. In regard to the tumor size, higher mean levels of IgG and IL-6 was shown in the tumor size (> 5 cm). Concerning to the tumor stages, the highest mean titer of IgG and IL-6 in patients with CA. Breast and CA.CRC whose are seropositive to anti-T. gondii IgG was in stage (IIIC). According to the grade status, the highest mean titer of IgG Abs and IL-6 was in patients with CA. Breast and CA.CRC whose are seropositive to anti-T. gondii IgG was in grade (G3). The increased levels of anti-T. gondii IgG and IL-6 was significantly higher in CA. Breast and CA. CRC patients that infected with T. gondii compare with healthy control. Thus, anti-T. gondii IgG test and circulating levels of inflammatory cytokines has to be taken into consideration as markers for staging of the cancers.

Published in International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 4)
DOI 10.11648/j.ijcocr.20170204.13
Page(s) 86-92
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Toxoplasma gondii, IL6 Levels, Breast, Colorectal Cancer

References
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    Dalya Falih Ahmed, Entsar Jabbar Saheb. (2017). The Association of Toxoplasma gondii Infection in Breast and Colorectal Cancer Patients. International Journal of Clinical Oncology and Cancer Research, 2(4), 86-92. https://doi.org/10.11648/j.ijcocr.20170204.13

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    Dalya Falih Ahmed; Entsar Jabbar Saheb. The Association of Toxoplasma gondii Infection in Breast and Colorectal Cancer Patients. Int. J. Clin. Oncol. Cancer Res. 2017, 2(4), 86-92. doi: 10.11648/j.ijcocr.20170204.13

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    AMA Style

    Dalya Falih Ahmed, Entsar Jabbar Saheb. The Association of Toxoplasma gondii Infection in Breast and Colorectal Cancer Patients. Int J Clin Oncol Cancer Res. 2017;2(4):86-92. doi: 10.11648/j.ijcocr.20170204.13

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  • @article{10.11648/j.ijcocr.20170204.13,
      author = {Dalya Falih Ahmed and Entsar Jabbar Saheb},
      title = {The Association of Toxoplasma gondii Infection in Breast and Colorectal Cancer Patients},
      journal = {International Journal of Clinical Oncology and Cancer Research},
      volume = {2},
      number = {4},
      pages = {86-92},
      doi = {10.11648/j.ijcocr.20170204.13},
      url = {https://doi.org/10.11648/j.ijcocr.20170204.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20170204.13},
      abstract = {Toxoplasma gondii is an obligatory intracellular protozoan parasite which is a major opportunistic pathogen in patients who are immunocompromised that having cancer disease. Little is known about the epidemiology of T. gondii infection in patients who are immunocompromised. This study investigate the possible association of T. gondii infection with cancer disease via determining the seropositivity rate of anti T. gondii antibodies (IgG and IgM) in Iraqi patients infected with breast and colorectal cancer and investigate the level of IL-6 in the studying groups. Overall 223 women serum samples that included 112 healthy controls samples and 111 samples with breast cancer (CA. Breast) and colorectal cancer (CA. CRC) enrolled in this study. The participants were tested for T. gondii immunoglobulins (IgG and IgM) antibodies and (IL-6) levels. The results showed that 86 (77.46%) cancer sample out of 111 samples and 23 (20.54%) out of 112 control samples were positive to anti T. gondii IgG. The seropositive rate of anti T. gondii IgG in CA. Breast and CA. CRC patients (77.50%, 77.42%) respectively compared with control group (20.54%). The present results revealed that the higher percentages for anti-T. gondii IgG and IL-6 titer was among patients with CA. Breast and CA. CRC whose are seropositive to anti T. gondii IgG. In regard to the tumor size, higher mean levels of IgG and IL-6 was shown in the tumor size (> 5 cm). Concerning to the tumor stages, the highest mean titer of IgG and IL-6 in patients with CA. Breast and CA.CRC whose are seropositive to anti-T. gondii IgG was in stage (IIIC). According to the grade status, the highest mean titer of IgG Abs and IL-6 was in patients with CA. Breast and CA.CRC whose are seropositive to anti-T. gondii IgG was in grade (G3). The increased levels of anti-T. gondii IgG and IL-6 was significantly higher in CA. Breast and CA. CRC patients that infected with T. gondii compare with healthy control. Thus, anti-T. gondii IgG test and circulating levels of inflammatory cytokines has to be taken into consideration as markers for staging of the cancers.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - The Association of Toxoplasma gondii Infection in Breast and Colorectal Cancer Patients
    AU  - Dalya Falih Ahmed
    AU  - Entsar Jabbar Saheb
    Y1  - 2017/08/18
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ijcocr.20170204.13
    DO  - 10.11648/j.ijcocr.20170204.13
    T2  - International Journal of Clinical Oncology and Cancer Research
    JF  - International Journal of Clinical Oncology and Cancer Research
    JO  - International Journal of Clinical Oncology and Cancer Research
    SP  - 86
    EP  - 92
    PB  - Science Publishing Group
    SN  - 2578-9511
    UR  - https://doi.org/10.11648/j.ijcocr.20170204.13
    AB  - Toxoplasma gondii is an obligatory intracellular protozoan parasite which is a major opportunistic pathogen in patients who are immunocompromised that having cancer disease. Little is known about the epidemiology of T. gondii infection in patients who are immunocompromised. This study investigate the possible association of T. gondii infection with cancer disease via determining the seropositivity rate of anti T. gondii antibodies (IgG and IgM) in Iraqi patients infected with breast and colorectal cancer and investigate the level of IL-6 in the studying groups. Overall 223 women serum samples that included 112 healthy controls samples and 111 samples with breast cancer (CA. Breast) and colorectal cancer (CA. CRC) enrolled in this study. The participants were tested for T. gondii immunoglobulins (IgG and IgM) antibodies and (IL-6) levels. The results showed that 86 (77.46%) cancer sample out of 111 samples and 23 (20.54%) out of 112 control samples were positive to anti T. gondii IgG. The seropositive rate of anti T. gondii IgG in CA. Breast and CA. CRC patients (77.50%, 77.42%) respectively compared with control group (20.54%). The present results revealed that the higher percentages for anti-T. gondii IgG and IL-6 titer was among patients with CA. Breast and CA. CRC whose are seropositive to anti T. gondii IgG. In regard to the tumor size, higher mean levels of IgG and IL-6 was shown in the tumor size (> 5 cm). Concerning to the tumor stages, the highest mean titer of IgG and IL-6 in patients with CA. Breast and CA.CRC whose are seropositive to anti-T. gondii IgG was in stage (IIIC). According to the grade status, the highest mean titer of IgG Abs and IL-6 was in patients with CA. Breast and CA.CRC whose are seropositive to anti-T. gondii IgG was in grade (G3). The increased levels of anti-T. gondii IgG and IL-6 was significantly higher in CA. Breast and CA. CRC patients that infected with T. gondii compare with healthy control. Thus, anti-T. gondii IgG test and circulating levels of inflammatory cytokines has to be taken into consideration as markers for staging of the cancers.
    VL  - 2
    IS  - 4
    ER  - 

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Author Information
  • Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq

  • Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq

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