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Peritoneal Cancer Indexes in Ovarian Carcinomatosis: Correlation Between CT and Intraoperative Results and Survival

Received: 26 January 2017     Accepted: 27 May 2017     Published: 1 August 2017
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Abstract

The aim of this study is to value the performance of computed tomography (CT) for the detection of ovarian peritoneal carcinomatosis (PC). We review retrospectively abdominopelvic CT and compare them with surgical reports to value the correlation between surgical and radiological PC indexes and survey. We compare the peritoneal tumor implants detected on CT performed before surgery with pathology results obtained after surgery. 47 patients with an average age of 58 years are investigated. Tumor localization and size are documented applying Sugarbaker´s Peritoneal Carcinomatosis Index (PCI) in both, radiological and surgical investigations, which divide the entire abdominal and intestinal regions into 13 spaces. In each one, the bigger visible lesion is measured and scored between 0 and 3. In our study, the correlation of Pearson shows there is a moderate correlation between the findings of the PCI obtained in the TC and surgical findings, appreciating a general low correlation in all regions, although the better results belong to regions 1, 2, 0 and 10. Also we observed a lower survival to greater PCI regarding carcinomatosis index in both TC and surgery. All patients received systemic chemotherapy before surgery, so its effect on the size of the peritoneal implants could explain the low correlation. In conclusion, we can consider that TC is a useful tool for the planning of the surgery and the preoperative treatments. The peritoneal cancer index is a significant index of survival in ovarian cancer patients and by using PCI a detailed evaluation of the peritoneal spread is possible being useful as a prognostic factor.

Published in International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 4)
DOI 10.11648/j.ijcocr.20170204.11
Page(s) 75-81
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Ovary, Carcinoma, Peritoneal Cavity, Computed Tomography, Surgery

References
[1] Modugno F, Edwards R. Ovarian Cancer: Prevention, Detection and Treatment of the Disease and Its Recurrence Molecular Mechanisms and Personalized Medicine Meeting Report. Int J Gynecol Cancer 2012; 22: 45- 57.
[2] Archer AG, Sugarbaker PH, Jelinek JS. Radiology of peritoneal carcinomatosis. Cancer Treat Res. 1996; 82: 263-88.
[3] Chang-Yun L, Yonemura Y, Ishibashi H, Sako S, Tsukiyama G, Kitai T, et al. Evaluation of preoperative computed tomography in estimating peritoneal cancer index in peritoneal carcinomatosis. Gan to Kagaku Ryoho. 2011; 38: 2060-4.
[4] Levy AD, Shaw JC, Sobin LH. From the Archives of the AFIP Secondary Tumors and Tumorlike Lesions of the Peritoneal Cavity: Imaging Features with Pathologic Correlation. Radio Graphics 2009; 29: 347-73.
[5] Cragun JM. Screening for ovarian cancer. Cancer Control. 2011; 18: 16-21.
[6] Mazzei MA, Khader L, Cirigliano A, Cioffi Squitieri N, Guerrini S, Forzoni B, et al. Accuracy of MDCT in the preoperative definition of Peritoneal Cancer Index (PCI) in patients with advanced ovarian cancer who underwent peritonectomy and hyperthermic intraperitoneal chemotherapy (HIPEC). Abdom Imaging. 2013; 38: 1422– 30.
[7] Muñoz-Casares FC, Rufián S, Rubio MJ, Lizárraga E, Díaz-Iglesias C, Aranda E, et al. Treatment of peritoneal carcinomatosis from ovarian cancer. Present, future directions and proposals. Clin Transl Oncol. 2007; 9; 652-62.
[8] Nougaret S, Addley HC, Colombo PE, Fujii S, Al Sharif SS, Tirumani SH, et al Ovarian carcinomatosis: how the radiologist can help plan the surgical approach. Radiographics. 2012; 32: 1775-800.
[9] Pannu HK, Bristow RE, Montz FJ, Fishman EK. Multidetector CT of Peritoneal Carcinomatosis from Ovarian Cancer. Radio Graphics. 2003; 23: 687-701.
[10] Jacquet P, Sugarbaker PH. Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis. Cancer Treat Res. 1996; 82: 359–74.
[11] Cotte E, Passot G, Gilly FN, Glehen O. Selection of patients and staging of peritoneal surface malignancies. World J Gastrointest Oncol. 2010; 15: 31-5.
[12] Esquivel J, Sticca R, Sugarbaker P, Levine E, Yan TD, Alexander R, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Ann Surg Oncol. 2007; 14: 128–33.
[13] Verwaal VJ, Kusamura S, Baratti D, Deraco M. The eligibility for local-regional treatment of peritoneal surface malignancy. J Surg Oncol. 2008; 98: 220–22.
[14] Nelson RC, Chezmar JL, Hoel MJ, Buck DR, Sugarbaker PH. Peritoneal carcinomatosis preoperative CT with intraperitoneal contrast material. Radiology. 1992; 182: 33-8.
[15] Tempany CM, Zou KH, Silverman SG, Brown DL, Kurtz AB, McNeil BJ. Staging of advanced ovarian cancer: comparison of imaging modalities– report from the Radiological Diagnostic Oncology Group. Radiology. 2000; 215: 761-7.
[16] Duhr C, Kenn W, Kickuth R, Kerscher AG, Germer CT, Hahn D, et al. Optimizing of preoperative computed tomography for diagnosis in patients with peritoneal carcinomatosis. World Journal of Surgical Oncology. 2011; 9: 171.
[17] Chandrashekhara SH, Thulkar S, Srivastava DN, Kumar L, Hariprasad R, Kumar S, et al. Pre-operative evaluation of peritoneal deposits using multidetector computed tomography in ovarian cancer. The British Journal of Radiology. 2011; 84: 38–43.
[18] Buy JN, Moss AA, Ghossain MA, Sciot C, Malbec L, Vadrot D, et al. Peritoneal implants from ovarian tumours: CT findings. Radiology 1988; 169: 691–4.
[19] Franiel T, Diederichs G, Engelken F, Elgeti T, Rost J, Rogalla P. Multidetector CT in peritoneal carcinomatosis: diagnostic role of thin slices and multiplanar reconstructions. Abdominal Imaging 2009, 34: 49-54.
[20] Metser U, Jones C, Jacks LM, Bernardini MQ, Ferguson S. Identification and Quantification of Peritoneal Metastases in Patients With Ovarian Cancer With Multidetector Computed Tomography Correlation With Surgery and Surgical Outcome. Int J Gynecol Cancer. 2011; 21: 1391-8.
[21] Spiliotis J, Halkia EE, Kalantzi N, Giassas S, Lianos E, Efstathiou E, et al.. Mapping the location of peritoneal metastases using the peritoneal cancer index and the correlation with overall survival: a retrospective study. J BUON. 2015 May; 20 Suppl 1: S64-70.
[22] Tentes AA, Tripsiannis G, Markakidis SK, Karanikiotis CN, Tzegas G, Georgiadis G, et al. Peritoneal cancer index: a prognostic indicator of survival in advanced ovarian cancer. European Journal of surgical oncology 2003, 29: 69.
[23] Rhonda L Harmon and Paul H Sugarbaker. Prognostic indicators in peritoneal carcinomatosis from gastrointestinal cancer. International Seminars in Surgical Oncology 2005; 2: 3.
[24] Ansell SM, Rapoport BL, Falkson G, Raats JI, Moeken CM. Survival determination in patients with advanced ovarian cancer. Gynecol Oncol 1993; 30: 215-20.
[25] Swenerton KD, Hislop TG, Spinelli J, LeRiche JC, Yang N, Boyes DA. Ovarian carcinoma: a multivariante analysis of prognostic factors. Obstet Gynecol 1985; 65: 264-9.
Cite This Article
  • APA Style

    Lombardo Galera Sagrario, Espejo Herrera Juan Jose, López Redondo Celia, Pérez Montilla Maria Eugenia, Muñoz Casares Francisco Cristobal, et al. (2017). Peritoneal Cancer Indexes in Ovarian Carcinomatosis: Correlation Between CT and Intraoperative Results and Survival. International Journal of Clinical Oncology and Cancer Research, 2(4), 75-81. https://doi.org/10.11648/j.ijcocr.20170204.11

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    ACS Style

    Lombardo Galera Sagrario; Espejo Herrera Juan Jose; López Redondo Celia; Pérez Montilla Maria Eugenia; Muñoz Casares Francisco Cristobal, et al. Peritoneal Cancer Indexes in Ovarian Carcinomatosis: Correlation Between CT and Intraoperative Results and Survival. Int. J. Clin. Oncol. Cancer Res. 2017, 2(4), 75-81. doi: 10.11648/j.ijcocr.20170204.11

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    AMA Style

    Lombardo Galera Sagrario, Espejo Herrera Juan Jose, López Redondo Celia, Pérez Montilla Maria Eugenia, Muñoz Casares Francisco Cristobal, et al. Peritoneal Cancer Indexes in Ovarian Carcinomatosis: Correlation Between CT and Intraoperative Results and Survival. Int J Clin Oncol Cancer Res. 2017;2(4):75-81. doi: 10.11648/j.ijcocr.20170204.11

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  • @article{10.11648/j.ijcocr.20170204.11,
      author = {Lombardo Galera Sagrario and Espejo Herrera Juan Jose and López Redondo Celia and Pérez Montilla Maria Eugenia and Muñoz Casares Francisco Cristobal and Zurera Tendero Luis Jesus},
      title = {Peritoneal Cancer Indexes in Ovarian Carcinomatosis: Correlation Between CT and Intraoperative Results and Survival},
      journal = {International Journal of Clinical Oncology and Cancer Research},
      volume = {2},
      number = {4},
      pages = {75-81},
      doi = {10.11648/j.ijcocr.20170204.11},
      url = {https://doi.org/10.11648/j.ijcocr.20170204.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20170204.11},
      abstract = {The aim of this study is to value the performance of computed tomography (CT) for the detection of ovarian peritoneal carcinomatosis (PC). We review retrospectively abdominopelvic CT and compare them with surgical reports to value the correlation between surgical and radiological PC indexes and survey. We compare the peritoneal tumor implants detected on CT performed before surgery with pathology results obtained after surgery. 47 patients with an average age of 58 years are investigated. Tumor localization and size are documented applying Sugarbaker´s Peritoneal Carcinomatosis Index (PCI) in both, radiological and surgical investigations, which divide the entire abdominal and intestinal regions into 13 spaces. In each one, the bigger visible lesion is measured and scored between 0 and 3. In our study, the correlation of Pearson shows there is a moderate correlation between the findings of the PCI obtained in the TC and surgical findings, appreciating a general low correlation in all regions, although the better results belong to regions 1, 2, 0 and 10. Also we observed a lower survival to greater PCI regarding carcinomatosis index in both TC and surgery. All patients received systemic chemotherapy before surgery, so its effect on the size of the peritoneal implants could explain the low correlation. In conclusion, we can consider that TC is a useful tool for the planning of the surgery and the preoperative treatments. The peritoneal cancer index is a significant index of survival in ovarian cancer patients and by using PCI a detailed evaluation of the peritoneal spread is possible being useful as a prognostic factor.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Peritoneal Cancer Indexes in Ovarian Carcinomatosis: Correlation Between CT and Intraoperative Results and Survival
    AU  - Lombardo Galera Sagrario
    AU  - Espejo Herrera Juan Jose
    AU  - López Redondo Celia
    AU  - Pérez Montilla Maria Eugenia
    AU  - Muñoz Casares Francisco Cristobal
    AU  - Zurera Tendero Luis Jesus
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    DO  - 10.11648/j.ijcocr.20170204.11
    T2  - International Journal of Clinical Oncology and Cancer Research
    JF  - International Journal of Clinical Oncology and Cancer Research
    JO  - International Journal of Clinical Oncology and Cancer Research
    SP  - 75
    EP  - 81
    PB  - Science Publishing Group
    SN  - 2578-9511
    UR  - https://doi.org/10.11648/j.ijcocr.20170204.11
    AB  - The aim of this study is to value the performance of computed tomography (CT) for the detection of ovarian peritoneal carcinomatosis (PC). We review retrospectively abdominopelvic CT and compare them with surgical reports to value the correlation between surgical and radiological PC indexes and survey. We compare the peritoneal tumor implants detected on CT performed before surgery with pathology results obtained after surgery. 47 patients with an average age of 58 years are investigated. Tumor localization and size are documented applying Sugarbaker´s Peritoneal Carcinomatosis Index (PCI) in both, radiological and surgical investigations, which divide the entire abdominal and intestinal regions into 13 spaces. In each one, the bigger visible lesion is measured and scored between 0 and 3. In our study, the correlation of Pearson shows there is a moderate correlation between the findings of the PCI obtained in the TC and surgical findings, appreciating a general low correlation in all regions, although the better results belong to regions 1, 2, 0 and 10. Also we observed a lower survival to greater PCI regarding carcinomatosis index in both TC and surgery. All patients received systemic chemotherapy before surgery, so its effect on the size of the peritoneal implants could explain the low correlation. In conclusion, we can consider that TC is a useful tool for the planning of the surgery and the preoperative treatments. The peritoneal cancer index is a significant index of survival in ovarian cancer patients and by using PCI a detailed evaluation of the peritoneal spread is possible being useful as a prognostic factor.
    VL  - 2
    IS  - 4
    ER  - 

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Author Information
  • Department of Interventional Radiology, Reina Sofia University Hospital, Córdoba, Spain

  • Department of Interventional Radiology, Reina Sofia University Hospital, Córdoba, Spain

  • Department of Radiology, Reina Sofia University Hospital, Córdoba, Spain

  • Department of Interventional Radiology, Reina Sofia University Hospital, Córdoba, Spain

  • Department of Interventional Radiology, Reina Sofia University Hospital, Córdoba, Spain

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