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Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma

Received: 27 December 2016     Accepted: 10 January 2017     Published: 9 February 2017
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Abstract

The aim of this study is to evaluate the decrease of biological effective dose (BED) and its correlation with local control of tumour in the treatment of nasopharyngeal carcinoma (NPC) when the overall treatment time is prolonged. A retrospective study was carried out on 39 NPC with stage II and III treated with fractionated High Dose Rate–Brachytherapy (HDR-BT)boost, following external beam radiation therapy (EBRT) treated in the period from 2009 to 2015. All patients were irradiated by HDR –Intra Luminal Radiotherapy (ILRT) following EBRT using a telecobalt unit and a technique that employed two lateral opposed fields with a dose of 66 ± 4 Gy. The total biological equivalent dose prescribed was 106.50 ± 9 Gy (range 92 - 123 Gy). The probabilities of disease recurrence within a median follow-up of 25 months (range 13 – 72 months) are expected as 0.03, 0.26, 0.58 and 0.90 (p=0.05) for the overall treatment time of 75, 150, 250 and 350 days respectively. It was observed that the local recurrence of disease increases with increased treatment time and it is significant (p=0.05) when the overall treatment time is above 100 days where BED lost becomes more than 0.10 Gy/day. The relative risk of local recurrence of stage III is about 2.59 times higher than that of stage II patients.

Published in International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 1)
DOI 10.11648/j.ijcocr.20170201.11
Page(s) 1-6
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

HDR-ILRT, Nasopharyngeal Cancer, BED, Treatment Time

References
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Cite This Article
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    Brahmacharimayum Arunkumar Sharma, Jayshree Phurailatpam, Gaurav Goswami, Thaodem Tomcha Singh, Laishram Jaichand Singh, et al. (2017). Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma. International Journal of Clinical Oncology and Cancer Research, 2(1), 1-6. https://doi.org/10.11648/j.ijcocr.20170201.11

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    ACS Style

    Brahmacharimayum Arunkumar Sharma; Jayshree Phurailatpam; Gaurav Goswami; Thaodem Tomcha Singh; Laishram Jaichand Singh, et al. Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma. Int. J. Clin. Oncol. Cancer Res. 2017, 2(1), 1-6. doi: 10.11648/j.ijcocr.20170201.11

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    AMA Style

    Brahmacharimayum Arunkumar Sharma, Jayshree Phurailatpam, Gaurav Goswami, Thaodem Tomcha Singh, Laishram Jaichand Singh, et al. Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma. Int J Clin Oncol Cancer Res. 2017;2(1):1-6. doi: 10.11648/j.ijcocr.20170201.11

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  • @article{10.11648/j.ijcocr.20170201.11,
      author = {Brahmacharimayum Arunkumar Sharma and Jayshree Phurailatpam and Gaurav Goswami and Thaodem Tomcha Singh and Laishram Jaichand Singh and Yengkhom Indibor Singh},
      title = {Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma},
      journal = {International Journal of Clinical Oncology and Cancer Research},
      volume = {2},
      number = {1},
      pages = {1-6},
      doi = {10.11648/j.ijcocr.20170201.11},
      url = {https://doi.org/10.11648/j.ijcocr.20170201.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20170201.11},
      abstract = {The aim of this study is to evaluate the decrease of biological effective dose (BED) and its correlation with local control of tumour in the treatment of nasopharyngeal carcinoma (NPC) when the overall treatment time is prolonged. A retrospective study was carried out on 39 NPC with stage II and III treated with fractionated High Dose Rate–Brachytherapy (HDR-BT)boost, following external beam radiation therapy (EBRT) treated in the period from 2009 to 2015. All patients were irradiated by HDR –Intra Luminal Radiotherapy (ILRT) following EBRT using a telecobalt unit and a technique that employed two lateral opposed fields with a dose of 66 ± 4 Gy. The total biological equivalent dose prescribed was 106.50 ± 9 Gy (range 92 - 123 Gy). The probabilities of disease recurrence within a median follow-up of 25 months (range 13 – 72 months) are expected as 0.03, 0.26, 0.58 and 0.90 (p=0.05) for the overall treatment time of 75, 150, 250 and 350 days respectively. It was observed that the local recurrence of disease increases with increased treatment time and it is significant (p=0.05) when the overall treatment time is above 100 days where BED lost becomes more than 0.10 Gy/day. The relative risk of local recurrence of stage III is about 2.59 times higher than that of stage II patients.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma
    AU  - Brahmacharimayum Arunkumar Sharma
    AU  - Jayshree Phurailatpam
    AU  - Gaurav Goswami
    AU  - Thaodem Tomcha Singh
    AU  - Laishram Jaichand Singh
    AU  - Yengkhom Indibor Singh
    Y1  - 2017/02/09
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    N1  - https://doi.org/10.11648/j.ijcocr.20170201.11
    DO  - 10.11648/j.ijcocr.20170201.11
    T2  - International Journal of Clinical Oncology and Cancer Research
    JF  - International Journal of Clinical Oncology and Cancer Research
    JO  - International Journal of Clinical Oncology and Cancer Research
    SP  - 1
    EP  - 6
    PB  - Science Publishing Group
    SN  - 2578-9511
    UR  - https://doi.org/10.11648/j.ijcocr.20170201.11
    AB  - The aim of this study is to evaluate the decrease of biological effective dose (BED) and its correlation with local control of tumour in the treatment of nasopharyngeal carcinoma (NPC) when the overall treatment time is prolonged. A retrospective study was carried out on 39 NPC with stage II and III treated with fractionated High Dose Rate–Brachytherapy (HDR-BT)boost, following external beam radiation therapy (EBRT) treated in the period from 2009 to 2015. All patients were irradiated by HDR –Intra Luminal Radiotherapy (ILRT) following EBRT using a telecobalt unit and a technique that employed two lateral opposed fields with a dose of 66 ± 4 Gy. The total biological equivalent dose prescribed was 106.50 ± 9 Gy (range 92 - 123 Gy). The probabilities of disease recurrence within a median follow-up of 25 months (range 13 – 72 months) are expected as 0.03, 0.26, 0.58 and 0.90 (p=0.05) for the overall treatment time of 75, 150, 250 and 350 days respectively. It was observed that the local recurrence of disease increases with increased treatment time and it is significant (p=0.05) when the overall treatment time is above 100 days where BED lost becomes more than 0.10 Gy/day. The relative risk of local recurrence of stage III is about 2.59 times higher than that of stage II patients.
    VL  - 2
    IS  - 1
    ER  - 

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Author Information
  • Department of Radiotherapy, Regional Cancer Centre, Regional Institute of Medical Sciences, Imphal, India

  • Department of Physiology, Regional Institute of Medical Sciences, Imphal, India

  • Department of Radiotherapy, Regional Cancer Centre, Regional Institute of Medical Sciences, Imphal, India

  • Department of Radiotherapy, Regional Cancer Centre, Regional Institute of Medical Sciences, Imphal, India

  • Department of Radiotherapy, Regional Cancer Centre, Regional Institute of Medical Sciences, Imphal, India

  • Department of Radiotherapy, Regional Cancer Centre, Regional Institute of Medical Sciences, Imphal, India

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