Purpose: The treatment of spinal cord injury (SCI) is a clinical challenge. The study attempted to investigate the effects of Tanshinone IIA on SCI in rats. Methods: The SCI model of rat was established based on Allen's animal model. The rats were randomly divided into four groups as follows: Control, Sham, SCI model, SCI + Tanshinone IIA. Rats were administrated with Tanshinone IIA (30mg/kg) respectively daily within one week after establishment of SCI model. Scores of Basso, Beattie, Bresnahan (BBB) was evaluated on the 1st, 3rd, 5th and 7th day after operation. Rats were sacrificed seven days after SCI, and the pathological injury of spinal cord tissue was assessed by HE staining. The levels of inflammatory cytokines (IL-1β and TNF-α) were detected by ELISA. Results: On the 7th day after operation, the BBB score of SCI + Tanshinone IIA group was significantly better than that of SCI group (P<0.01). Compared with SCI group, the pathological changes, neuronal pyknosis, hemorrhage, inflammatory infiltration, and white matter cavity formation in SCI + Tanshinone IIA group were reduced. Compared with SCI group, the level of IL-1 β and TNF-α in SCI+ Tanshinone IIA group were significantly lower (P<0.01). Conclusion: Tanshinone IIA can significantly improve motor function inhibit inflammation and repair spinal cord function after SCI.
| Published in | Clinical Medicine Research (Volume 13, Issue 2) |
| DOI | 10.11648/j.cmr.20241302.11 |
| Page(s) | 17-22 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Tanshinone IIA, Spinal Cord Injury, Inflammatory
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APA Style
Lin, B., Lin, A., Chen, W. (2024). Tanshinone IIA Regulate Inflammatory Response and Promote Functional Recovery in Rats with Spinal Cord Injury. Clinical Medicine Research, 13(2), 17-22. https://doi.org/10.11648/j.cmr.20241302.11
ACS Style
Lin, B.; Lin, A.; Chen, W. Tanshinone IIA Regulate Inflammatory Response and Promote Functional Recovery in Rats with Spinal Cord Injury. Clin. Med. Res. 2024, 13(2), 17-22. doi: 10.11648/j.cmr.20241302.11
AMA Style
Lin B, Lin A, Chen W. Tanshinone IIA Regulate Inflammatory Response and Promote Functional Recovery in Rats with Spinal Cord Injury. Clin Med Res. 2024;13(2):17-22. doi: 10.11648/j.cmr.20241302.11
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Download@article{10.11648/j.cmr.20241302.11,
author = {Bin Lin and Aini Lin and Weiting Chen},
title = {Tanshinone IIA Regulate Inflammatory Response and Promote Functional Recovery in Rats with Spinal Cord Injury
},
journal = {Clinical Medicine Research},
volume = {13},
number = {2},
pages = {17-22},
doi = {10.11648/j.cmr.20241302.11},
url = {https://doi.org/10.11648/j.cmr.20241302.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20241302.11},
abstract = {Purpose: The treatment of spinal cord injury (SCI) is a clinical challenge. The study attempted to investigate the effects of Tanshinone IIA on SCI in rats. Methods: The SCI model of rat was established based on Allen's animal model. The rats were randomly divided into four groups as follows: Control, Sham, SCI model, SCI + Tanshinone IIA. Rats were administrated with Tanshinone IIA (30mg/kg) respectively daily within one week after establishment of SCI model. Scores of Basso, Beattie, Bresnahan (BBB) was evaluated on the 1st, 3rd, 5th and 7th day after operation. Rats were sacrificed seven days after SCI, and the pathological injury of spinal cord tissue was assessed by HE staining. The levels of inflammatory cytokines (IL-1β and TNF-α) were detected by ELISA. Results: On the 7th day after operation, the BBB score of SCI + Tanshinone IIA group was significantly better than that of SCI group (PConclusion: Tanshinone IIA can significantly improve motor function inhibit inflammation and repair spinal cord function after SCI.
},
year = {2024}
}
TY - JOUR T1 - Tanshinone IIA Regulate Inflammatory Response and Promote Functional Recovery in Rats with Spinal Cord Injury AU - Bin Lin AU - Aini Lin AU - Weiting Chen Y1 - 2024/04/29 PY - 2024 N1 - https://doi.org/10.11648/j.cmr.20241302.11 DO - 10.11648/j.cmr.20241302.11 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 17 EP - 22 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20241302.11 AB - Purpose: The treatment of spinal cord injury (SCI) is a clinical challenge. The study attempted to investigate the effects of Tanshinone IIA on SCI in rats. Methods: The SCI model of rat was established based on Allen's animal model. The rats were randomly divided into four groups as follows: Control, Sham, SCI model, SCI + Tanshinone IIA. Rats were administrated with Tanshinone IIA (30mg/kg) respectively daily within one week after establishment of SCI model. Scores of Basso, Beattie, Bresnahan (BBB) was evaluated on the 1st, 3rd, 5th and 7th day after operation. Rats were sacrificed seven days after SCI, and the pathological injury of spinal cord tissue was assessed by HE staining. The levels of inflammatory cytokines (IL-1β and TNF-α) were detected by ELISA. Results: On the 7th day after operation, the BBB score of SCI + Tanshinone IIA group was significantly better than that of SCI group (PConclusion: Tanshinone IIA can significantly improve motor function inhibit inflammation and repair spinal cord function after SCI. VL - 13 IS - 2 ER -
Department of Orthopedics, Taizhou Integrated Chinese and Western Medicine Hospital, Taizhou, China
Department of Emergency and Intensive Care Unit, The First People's Hospital of Linhai, Taizhou, China
